Succulent

 

OUR TECHNOLOGY

 

Nature provides us with countless chemicals that can improve our lives. Trees and plants often supply them, but in such small amounts that they’re hard to extract, leading to waste and environmental degradation.  To harness natural chemicals more effectively, synthetic biology first attempted to rewire living cells to make them easier to extract.  But cells are complicated and not easily rewired.

Invizyne’s new approach streamlines synthetic biology by removing cells altogether, along with their complexities.  Using our proprietary, sustainable enzyme systems we can build simple, efficient reactors for chemical production. Unleashing enzymes for production outside the cell allows us to achieve the safety, sustainability and diversity found in nature, along with the scale found in traditional chemical manufacturing.

 

The Invizyne approach allows for:

  • Fast design-build-test-learn cycles for rapid optimization

  • Higher yields due to lack of competing pathways

  • Higher titers without toxicity constraints

  • Reliable scaling of production

  • Simplified product purification

  • cGMP Level Production

 

Our cell-free platform has proven effective for producing a wide variety of compounds: 

  • Natural ingredients: cannabinoids, flavors, fragrances, nutraceuticals 

  • Pharmaceuticals: natural products with therapeutic properties 

  • Chemicals: commodity chemicals, specialty chemicals

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ADP

ATP

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ADP

ATP

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NADH

NAD+

NADH

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NAD+

(SUBSTRATE)

(PRODUCT)

S

A

B

C

D

E

P

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Publications and Intellectual Property

 

SimplePath is based on intellectual property developed at UCLA by our founders, which describes enzymatic pathways that allow for cofactor regeneration in a cell-free system. Through the licensed technology and our further innovations, we build robust, continuous cell-free systems that run for prolonged periods of time at high productivity and high titers.  Our published concepts can be found in the following publications: